For the first half of the twentieth century, the cause of schizophrenia was thought to be:

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During the first half of the twentieth century, the cause of schizophrenia was often attributed to what was termed "inappropriate parenting," particularly by the mother. This theory, sometimes referred to as the "refrigerator mother" hypothesis, suggested that cold, distant, or otherwise dysfunctional maternal care could lead to the development of schizophrenia in children. This perspective has since been discredited in favor of understandings that emphasize genetic, biological, and environmental factors.

For the First Half of the Twentieth Century, the Cause