Which of the Following Is True of Spain's Explorations of the New

Which of the following is true of Spain's explorations of the New World?

A) Individual conquistadores always traveled alone.
B) Members of the Spanish parties suffered greatly from disease.
C) Florida was the first region in the present-day United States that Spain colonized.
D) Spain sought to forestall Portuguese incursions into the New World.
E) Spain's explorations had no impact on the size of the Native American population.