A 45-Year-Old Female Complains of Recent Weight Gain, Amenorrhea for 3

A 45-year-old female complains of recent weight gain, amenorrhea for 3 months, and bruising. No current medications. Medical and surgical history positive for cholecystectomy at age 41. On review of systems, the patient reveals hair growth on face, acne, and easy bruisability. Vital signs are: afebrile, pulse 80 beats/min, respirations 12 breaths/min, blood pressure 148/92. Physical examination shows abdominal obesity and striae over abdomen. Which of the following questions is most helpful toward a differential diagnosis?

A) Have you used corticosteroids in the last month?
B) How much weight have you gained in the last 3 months?
C) Have you had any bleeding episodes, such as nosebleeds or gums bleeding?
D) Is cancer in the family history?