Which of the following is the correct order of the pathway by which activation of PI3-kinase stimulates cell division? A)PIP₃ formation-Akt phosphorylation-TOR activation-Rheb activation B)PIP₃ formation-TOR activation-Rheb activation-Akt phosphorylation C)Akt phosphorylation-TOR activation-Rheb activation-PIP₃ formation D)PIP₃ formation-Akt phosphorylation-Rheb activation-TOR activation E)Akt phosphorylation-PIP₃ formation-TOR activation-Rheb activation

Question

Quizplus · Accepted Answer

The correct sequence starts with the formation of PIP3 (phosphatidylinositol (3,4,5)-trisphosphate) following the activation of PI3-kinase. This leads to the phosphorylation of Akt (also known as Protein Kinase B), which then activates Rheb (Ras homolog enriched in brain), a small GTPase that ultimately activates the TOR (Target of Rapamycin) pathway, promoting cell division and growth.

Which of the Following Is the Correct Order of the Pathway