Inhibitors of which of the following would interfere with nitric oxide stimulation of cardiac artery dilation through relaxation of smooth muscle cells?
A)protein kinase G.
B)nitric oxide synthase
C)guanylyl cyclase
D)calmodulin
E)Inhibitors of all of the above would interfere with nitric oxide stimulation.

Question

Quizplus · Accepted Answer

Inhibitors of protein kinase G, nitric oxide synthase, guanylyl cyclase, and calmodulin would all interfere with nitric oxide stimulation of cardiac artery dilation. Nitric oxide synthase is responsible for the production of nitric oxide. Nitric oxide then activates guanylyl cyclase, which converts GTP to cGMP. cGMP acts as a second messenger to activate protein kinase G, which then leads to the relaxation of smooth muscle cells and thus dilation of the arteries. Calmodulin is involved in the activation of nitric oxide synthase. Therefore, inhibiting any of these components would disrupt the pathway and interfere with the process.

Inhibitors of Which of the Following Would Interfere with Nitric