A 40-year-old patient has been diagnosed with cancer.Sequencing of cancer cell genomes reveals a high frequency of G/C to A/T base pairs conversion.The DNA repair system that is most likely deficient in this patient is the
A)base excision repair pathway.
B)SOS repair pathway.
C)nonhomologous end-joining pathway.
D)nucleotide excision repair pathway.
E)synthesis-dependent strand annealing pathway.

Question

Quizplus · Accepted Answer

The base excision repair pathway is responsible for correcting small base lesions, such as G/C to A/T base pair conversions, by removing and replacing the incorrect bases. This pathway is crucial for fixing mutations that arise from deamination, oxidation, and other processes that alter the structure of individual nucleotides.

A 40-Year-Old Patient Has Been Diagnosed with Cancer