Allosteric Regulation of Key Enzymes in Glycolytic and Gluconeogenesis Pathways

Allosteric regulation of key enzymes in glycolytic and gluconeogenesis pathways may involve each of the following except

A) activating the enzyme activity.
B) inhibiting the enzyme activity.
C) binding of the allosteric regulator molecule to directly compete with substrate binding in the enzyme active site.
D) binding of the allosteric regulator molecule to a site on the enzyme other than the active site.
E) Any of the above may be involved.