The Active Site for Many Enzymes

The active site for many enzymes

A) contains amino acids that are contiguous to one another along the primary sequence of the protein.
B) may require a prosthetic group such as a metal ion.
C) involves amino acids that are brought into close proximity by extensive protein folding.
D) usually depends on only one amino acid.
E) involves amino acids that are brought into close proximity by extensive protein folding and may require a prosthetic group such as a metal ion.