How Do Large Polar and Charged Molecules Cross Biological Membranes

How do large polar and charged molecules cross biological membranes?

A) Large polar and charged molecules can't cross biological membranes.
B) Large polar and charged molecules cross biological membranes via diffusion through the hydrophilic core of the membrane.
C) Large polar and charged molecules must be hydrolyzed before they can cross a biological membrane.
D) Large polar and charged molecules cross biological membranes via transport proteins that form hydrophilic channels through the membrane.
E) Both A and C