When the results of a GWAS experiment using 500,000 SNPs are plotted in a Manhattan plot, significantly associated SNPs are
A)data points with a ‒log (p value)less than 0.05.
B)data points with a ‒log (p value)greater than 7.
C)data points with a ‒log (p value)greater than 7 that fall within a known coding sequence.
D)any data points above the line of correlation.

Question

Quizplus · Accepted Answer

In a Manhattan plot, significantly associated SNPs are typically those with a -log(p-value) greater than a certain threshold, often set at 7, which corresponds to a p-value of 0.0000001 (or 1e-7), indicating a highly significant association.

When the Results of a GWAS Experiment Using 500,000 SNPs