Although Bacteria Can Be Used to Produce Proteins for Therapeutic

Although bacteria can be used to produce proteins for therapeutic uses, what can be a disadvantage to using a prokaryotic system?

A) Proteins may not be posttranslationally processed correctly.
B) Transcripts from eukaryotic open reading frames are degraded quickly in prokaryotic cells.
C) Some prokaryotic promoters do not work well to transcribe eukaryotic open reading frames.
D) The structures that eukaryotic mRNAs fold into are frequently used as rho termination signals.