Transgenic animals made by pronuclear injection can be limited for studies of the links between genes and disease because
A)the transgene allele must be dominant to the normal, endogenous allele and some diseases are caused by recessive mutations.
B)the transgene allele must be recessive to the normal, endogenous allele and some diseases are caused by dominant mutations.
C)all diseases are caused by mutations in multiple genes.
D)diseases are not caused by specific alleles of a gene, but by posttranslational modifications of proteins.

Question

Quizplus · Accepted Answer

Transgenic animals made by pronuclear injection can be limited because the transgene allele must be dominant to the normal, endogenous allele for its effects to be observed, and some diseases are indeed caused by recessive mutations, making it difficult to model these diseases with this method.

Transgenic Animals Made by Pronuclear Injection Can Be Limited for Studies