Inversions Are Most Likely to Affect an Organism's Phenotype

Inversions are most likely to affect an organism's phenotype

A) if one or both of the inversion's breakpoints lies within the transcribed region of a gene.
B) if the inversion's breakpoints are on either side of a gene and its regulatory regions and the entire gene is reversed in the genome.
C) if the inversion is pericentric.
D) if the inversion is paracentric.
E) if the inversion is small.