Which disease results from deletion of the β-globin gene cluster LCR?
A)sickle-cell disease
B)mild α-thalassemia
C)severe α-thalassemia
D)mild β-thalassemia
E)severe β-thalassemia

Question

Quizplus · Accepted Answer

Severe β-thalassemia, also known as β-thalassemia major, results from mutations or deletions that significantly affect the β-globin gene, including disruptions to the locus control region (LCR) which is crucial for the expression of the β-globin gene cluster.

Which Disease Results from Deletion of the β-Globin Gene Cluster