A mutation creates a dominant negative allele of a particular gene.The gene encodes a protein that forms a trimer within the cell.If one or more of the subunits has the mutant structure, the entire trimeric protein is inactive.In a heterozygous cell, if the proteins of both alleles are present at the same levels, what percent of the trimers present in the cell will be active?
A)100%
B)87.5%
C)50%
D)33%
E)12.5%

Question

Quizplus · Accepted Answer

In a heterozygous cell, each trimer can be composed of any combination of wild-type and mutant subunits. The probability of a trimer being fully wild-type (and thus active) is (1/2)^3 = 1/8, or 12.5%, since each subunit has a 50% chance of being wild-type.

A Mutation Creates a Dominant Negative Allele of a Particular