The base analog 5-bromouracil can tautomerize.One tautomer behaves like thymine and the other behaves like cytosine.If 5-bromouracil is used as a mutagen, what is the minimum number of times replication must occur to mutate the codon for proline (CCC)into the codon for serine (TCC)?
A)one generation
B)two generations
C)three generations
D)5-bromouracil cannot induce this mutation

Question

Quizplus · Accepted Answer

Two generations are required for the mutation from proline (CCC) to serine (TCC) using 5-bromouracil. In the first replication, 5-bromouracil pairs with adenine (mimicking thymine), converting C to T in one strand. In the second replication, the original strand with C pairs normally, but the mutated strand with T pairs with A, solidifying the mutation from C to T.

The Base Analog 5-Bromouracil Can Tautomerize