The condition sickle cell anemia is due to
A)the insertion of an amino acid.
B)the deletion of an amino acid.
C)substitution of an amino acid.
D)failure to synthesize a hemoglobin molecule.
E)deletion of the β-chain hemoglobin gene.

Question

Quizplus · Accepted Answer

Sickle cell anemia is caused by a substitution of the amino acid valine for glutamic acid at the sixth position of the beta chain of hemoglobin. This single amino acid change alters the hemoglobin molecule's properties, leading to the sickling of red blood cells under certain conditions.

The Condition Sickle Cell Anemia Is Due to