To Prevent Systemic Absorption of Timolol (Timoptic),what Administration Instructions Are

To prevent systemic absorption of timolol (Timoptic) ,what administration instructions are appropriate for the nurse to include in the teaching?

A) Apply pressure over the lacrimal sac for 1 minute.
B) Wait 5 minutes before administering other ophthalmic solutions.
C) Administer the eyedrop in the conjunctival sac.
D) Remove contact lenses prior to administering eyedrops.