If the Most Pessimistic Assumptions in the Drake Equation Were

If the most pessimistic assumptions in the Drake equation were true, we would

A) have to wait millions of years to get a message back from the nearest intelligent life.
B) have to wait approximately 40 years to get a message back from the nearest intelligent life.
C) certainly be the only intelligent life in the universe.
D) need to concentrate on the Andromeda Galaxy when searching for intelligent life.
E) need to concentrate on the most distant galaxies to find signs of intelligent life.