What Was Antwerp's Claim to Fame in the Sixteenth Century

What was Antwerp's claim to fame in the sixteenth century?

A) It housed the largest fish market in the world.
B) Its merchants were the first to sell black slaves at a European port.
C) Although only a city, its citizens repelled Spanish troops in three invasion battles.
D) It was the trading center of Europe, brokering huge financial transactions.
E) It was the first European port to permit access to Muslim merchants.