Which of the following is an example of linkage disequilibrium?
A) The actual occurrence of haplotype HLA-B7 and HLA-Cw5 is 6%; the expected occurrence based on gene frequencies is 5%.
B) The actual occurrence of haplotype HLA-C4 and HLA-B37 is 3%; the expected occurrence based on gene frequencies is 4%.
C) The actual occurrence of haplotype HLA-A1 and HLA-B8 is 8%; the expected occurrence based on gene frequencies is 2%.
D) The actual occurrence of haplotype HLA-A11 and HLA-DR4 is 8%; the expected occurrence based on gene frequencies is 7%.

Question

Quizplus · Accepted Answer

Linkage disequilibrium occurs when the actual occurrence of a haplotype is significantly different from the expected occurrence based on gene frequencies. In this case, the actual occurrence of haplotype HLA-A1 and HLA-B8 is 8%, while the expected occurrence based on gene frequencies is 2%. This indicates that these two alleles are linked and are more likely to be inherited together than expected by chance.

Which of the Following Is an Example of Linkage Disequilibrium