Which of the following is a proposed theory for methyldopa-induced mechanism of immune hemolytic anemia?
A) Normal red blood cell antigens are altered by the drug and are no longer recognized as "self," resulting in production of alloantibody to these red blood cell antigens.
B) The drug affects the synthesis of IgG, exerting a direct effect on T lymphocytes, which results in a loss of suppressor function and subsequent proliferation of autoantibodies by B lymphocytes.
C) The drug produces aberrations in the proliferation of normal lymphocytes, producing clones of normal immunologically competent cells, which produces antibody against foreign red blood cell antigens.
D) The drug modifies the red blood cells so that plasma proteins bind to the membrane.
Correct Answer:
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A)
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