What is the physiological cause of citrate toxicity in cytapheresis procedures?
A) The extracorporeal blood volume leaks citrate into the reinfusion site of the donor.
B) The anticoagulant in plasma contains citrate, which binds calcium, lowering the body's ionized calcium.
C) The anticoagulant in plasma contains citrate, which binds chloride, lowering the anion gap.
D) None of the above.

Question

Quizplus · Accepted Answer

Citrate is used as an anticoagulant in cytapheresis procedures and works by binding to calcium ions, which are necessary for blood clotting. This binding reduces the level of ionized calcium in the blood, potentially leading to citrate toxicity if the body cannot compensate quickly enough.

What Is the Physiological Cause of Citrate Toxicity in Cytapheresis