What can be done to prevent the development of HLA alloimmunization and platelet refractoriness?
A) Test the donor for the presence of platelet antibodies.
B) Issue only cytomegalovirus-negative platelets.
C) Irradiate the platelet concentrate.
D) Reduce the number of leukocytes in the platelet product.

Question

Quizplus · Accepted Answer

Reducing the number of leukocytes in the platelet product (leukoreduction) helps prevent HLA alloimmunization and platelet refractoriness by minimizing the exposure to foreign HLA antigens present on leukocytes.

What Can Be Done to Prevent the Development of HLA