What Is the Physiologic Mechanism of Histamine

What is the physiologic mechanism of histamine?

A) Histamine is released when the allergen-reagin complex attaches to the surface of basophils, increasing vascular dilation and permeability
B) Histamine is released when the allergen-reagin complex attaches to the surface of tissue mast cells, increasing vascular dilation and permeability
C) Histamine is released when the allergen-reagin complex attaches to the surface of eosinophils, increasing vascular dilation and permeability
D) Histamine is released when the allergen-reagin complex attaches to the surface of tissue mast cells, decreasing vascular dilation and permeability