A 2-unit crossmatch was ordered on a patient in the emergency room. The patient's antibody screen was negative. One unit was compatible and the other was incompatible at AHG. If the patient's antibody screen was negative and the donor had no history of antibodies, what could be the reason for this reaction?
A) The patient's serum has an antibody to a low-frequency antigen not present on screening cells.
B) The donor has a positive DAT.
C) The patient's serum has an HTLA antibody.
D) Options A and B

Question

Quizplus · Accepted Answer

The patient's serum may have an antibody to a low-frequency antigen not present on screening cells, or the donor may have a positive DAT, both of which could cause the observed incompatibility.

A 2-Unit Crossmatch Was Ordered on a Patient in the Emergency