A patient with multiple myeloma exhibits rouleaux formation in an immediate spin crossmatch. What procedure is recommended to distinguish true red blood cell agglutination from nonspecific agglutination?

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Quizplus · Accepted Answer

Saline dilution is recommended to distinguish true red blood cell agglutination from nonspecific agglutination. In saline dilution, the sample is diluted with saline, which reduces the concentration of the antibodies and other proteins that can cause nonspecific agglutination. If the agglutination is due to true red blood cell agglutination, it will persist even after dilution, while nonspecific agglutination will be reduced or eliminated.

A Patient with Multiple Myeloma Exhibits Rouleaux Formation in an Immediate