Which is the route of administration by which the largest proportion of the drug dose is likely lost before reaching the site of action?

Name: Which is the route of administration by which the largest proportion of the drug dose is likely lost before reaching the site of action?
Brand: Quizplus
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Question

Quizplus · Accepted Answer

The oral route of administration is subject to first-pass metabolism in the liver, where a significant portion of the drug can be metabolized before reaching systemic circulation and the site of action.

Which Is the Route of Administration by Which the Largest