Staging Systems Used to Classify a Malignant Tumor at the Time

Staging systems used to classify a malignant tumor at the time of diagnosis are based on which of the following factors?

A) Size of the tumor, involvement of lymph nodes, metastases
B) Location of tumor, size, type of cellular abnormality
C) Size, encapsulated or non-encapsulated, invasion into neighboring tissue
D) Type of cellular abnormality, size of secondary tumors, location/tissue affected