Leukemia is sometimes linked to chromosome abnormalities, as evidenced by:
A) the presence of Philadelphia chromosome translocation in cases of acute myelogenous leukemia (AML).
B) very low incidence in persons with Down syndrome.
C) little evidence of familial incidence.
D) transmission as a recessive gene.

Question

Quizplus · Accepted Answer

The Philadelphia chromosome translocation is a specific chromosomal abnormality that is found in cases of acute myelogenous leukemia (AML). This translocation involves the exchange of genetic material between chromosomes 9 and 22, and it results in the formation of a fusion gene called BCR-ABL. The BCR-ABL fusion gene encodes a protein that is constitutively active, and this can lead to the development of AML.

Leukemia Is Sometimes Linked to Chromosome Abnormalities, as Evidenced By