Familial hypercholesterolemia, an autosomal dominant disease, is five times more frequent in the Afrikaner population of South Africa than in the original population of Europe from which the ancestors to the Afrikaners emigrated.This represents an example of

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The founder effect occurs when a small group of individuals becomes isolated from a larger population, leading to a higher frequency of certain genetic traits in the new population, as seen in the Afrikaner population with familial hypercholesterolemia.

Familial Hypercholesterolemia, an Autosomal Dominant Disease, Is Five Times More