Which Statement Accurately Describes the Effects of Substrate and Enzyme

Which statement accurately describes the effects of substrate and enzyme concentrations on reaction rate?

A) An increase in either substrate or enzyme concentration will increase the reaction rate.
B) An increase in either substrate or enzyme concentration will decrease the reaction rate.
C) An increase in substrate concentration increases the reaction rate, but enzyme concentration has no effect.
D) A decrease in substrate concentration or an increase in enzyme concentration increases the reaction rate.
E) An increase in substrate concentration or a decrease in enzyme concentration will increase the reaction rate.