Order: Polymixin B sulfate 25,000 units/kg/d in four equally divided doses IM. The label on the vial reads 500,000 units.The manufacturer recommends diluting 500,000 units with 5 ml of sterile water.How many milliliters will you prepare for a single dose if the patient weighs 150 pounds?

Question

Quizplus · Accepted Answer

The patient's weight in kilograms is 150 pounds / 2.2 = 68.2 kg. The daily dose is 25,000 units/kg/d, so the total daily dose is 25,000 units/kg/d x 68.2 kg = 1,705,000 units. The vial contains 500,000 units, so the number of vials needed is 1,705,000 units / 500,000 units = 3.41 vials. The manufacturer recommends diluting 500,000 units with 5 ml of sterile water, so the total volume of diluent needed is 3.41 vials x 5 ml/vial = 17.05 ml. The single dose is one-fourth of the total daily dose, so the volume of diluent needed for a single dose is 17.05 ml / 4 = 4.26 ml.

Order: Polymixin B Sulfate 25,000 Units/kg/d in Four Equally Divided