The Nursing Instructor Teaches Student Nurses About Chemotherapy for Cancer

The nursing instructor teaches student nurses about chemotherapy for cancer. Which statement best explains why lung cancers are less sensitive to antineoplastic agents than other types of cancers?

A) "Lung cancer cells have a very erratic cell cycle, and this is why there isn't much difference between the number of replicating and resting cells."
B) "Lung cancer cells have been growing for a long time before detection, so they are less sensitive to antineoplastic agents."
C) "Lung cancer cells have a low-growth fraction, which means there isn't much difference between the number of replicating and resting cells."
D) "Lung cancer cells grow in a high-oxygen environment, so they are not very sensitive to antineoplastic agents."