Tacrolimus (FK-506)is a drug that inhibits an enzyme called calcineurin.Calcineurin is a protein phosphatase.This is an enzyme that dephosphorylates (removes phosphate groups)from proteins.When added to cells,tacrolimus can inhibit the dephosphorylation of a protein called NFAT,but it cannot prevent the dephosphorylation of a protein called CDK1.What is the most likely explanation for this finding?

Question

Quizplus · Accepted Answer

The fact that tacrolimus inhibits the dephosphorylation of NFAT but not CDK1 suggests that NFAT is a substrate of calcineurin, while CDK1 is not. Therefore, when calcineurin is inhibited by tacrolimus, NFAT is affected but CDK1 is not.

Tacrolimus (FK-506)is a Drug That Inhibits an Enzyme Called Calcineurin