Glycogen Storage Disease Type II (GSD II), also known as Pompe disease, is a metabolic disorder that leads to the accumulation of glycogen in muscles and neurons throughout the body.It is caused by a defect in an enzyme that is normally housed with other enzymes that are involved in breaking down large macromolecules.What organelle is most likely affected by this disease?
A)Lysosome
B)Golgi body
C)Nucleus
D)Mitochondrion

Question

Quizplus · Accepted Answer

Pompe disease is caused by a deficiency of the enzyme acid alpha-glucosidase, which is located in the lysosome. This enzyme is responsible for breaking down glycogen into glucose within the lysosome, so its deficiency leads to glycogen accumulation in this organelle.

Glycogen Storage Disease Type II (GSD II), Also Known as Pompe