Pain receptors are activated by tissue damage,but pain perception requires intact,functional neurons.How does this work?

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Quizplus · Accepted Answer

Pain receptors (nociceptors) are activated by tissue damage, but the perception of pain requires intact, functional neurons. When tissue damage occurs, damaged cells release chemicals such as prostaglandins, histamines, and cytokines. These chemical signals then bind to the nociceptors located in nearby nerve endings and activate them, sending signals up the spinal cord to the brain. The neuron itself does not need to be damaged for pain perception to occur; it responds to signals released by nearby damaged cells.

Pain Receptors Are Activated by Tissue Damage,but Pain Perception Requires