Why Was the Spanish City of Manila Important to the Emerging

Why was the Spanish city of Manila important to the emerging trans-Pacific trade?

A) Mexican silver brought to Manila flowed into the Indian Ocean trade.
B) Manila became the main Spanish naval center for the Pacific Spanish empire.
C) A major missionary effort began in Manila to correspond with the new trade network.
D) Manila's presence helped to destroy Dutch and Portuguese trade in the Philippines.
E) Manila was a trade depot for the growing slave trade.