What Is a Major Difference in Using Lod-Score Analysis Compared

What is a major difference in using lod-score analysis compared to using association studies in determining gene locations in humans?

A) Lod-score analysis relies on family or pedigree data, while association studies use population data.
B) Lod-score analysis requires that the loci being mapped must be on different chromosome arms, while association studies can map genes on different chromosomes.
C) Association studies compare genotypes between parents and their children, while lod-score analysis compares genotypes between siblings of the same family.
D) Lod-score analysis requires isolated human populations, while association studies require very large family pedigrees.
E) Lod-score analysis requires a large number of genes with multiple alleles, while association studies can use genes that have only two alleles.