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Marsupials, Like Cats, Achieve Dosage Compensation by X Inactivation

Question 84

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Marsupials, like cats, achieve dosage compensation by X inactivation. You are working in a lab that has discovered a mutation on the X chromosome in marsupials in the same gene that causes the tortoiseshell fur color phenotype in cats. You cross an X+Y black-furred male with an XOXO orange-furred female. You expect that the X+XO female progeny will have tortoiseshell fur (like cats). Surprisingly, you find that all the females (n = 25) have solid orange fur. Offer a hypothesis to explain these results and describe a genetic test to support your hypothesis.

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