A cell is unable to progress into the S phase of the cell cycle. Further studies indicate that the RB-E2F complex is unable to dissociate in this cell and thus remains together. Which of the following genes is MOST likely mutated?

Question

Quizplus · Accepted Answer

Cyclin-dependent kinases (CDKs) are responsible for phosphorylating the RB protein, leading to the dissociation of the RB-E2F complex, allowing the cell to progress into the S phase. A mutation in a gene encoding a CDK could prevent this phosphorylation, keeping the RB-E2F complex intact and blocking cell cycle progression.

A Cell Is Unable to Progress into the S Phase