Somatic cancer cells often are unstable and divide inappropriately (divide when they should not be dividing). In addition such cells often contain losses of some chromosomes and extra copies of other chromosomes. Defects in which of the following may be partially responsible for the aberrant behavior of cancer cells? (Select all that apply.) A) spindle-assembly checkpoint B) G₁/S checkpoint C) homologous chromosome pairing D) crossing over

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Quizplus · Accepted Answer

The spindle-assembly checkpoint ensures chromosomes are properly attached to the spindle before division, preventing chromosome loss or gain. The G1/S checkpoint controls cell cycle progression, preventing inappropriate division. Defects in these checkpoints can lead to the instability seen in cancer cells.

Somatic Cancer Cells Often Are Unstable and Divide Inappropriately (Divide