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Question 58

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Refer to the following sequence:
5' ...GGAGCUCGUUGUAUU... 3'
-The nucleotide sequence 5'...GGAGCUCGUUGUAUU... 3' is changed to 5'GGAGACUCGUUGUAUU 3'. Why does or why doesn't the amino acid sequence change?


A) The reading frame changes after the mutation (the addition of an A in the fifth position) and so the amino acid sequence is modified after that point.
B) The reading frame, starting at the 5' end of this sequence, would be modified because of this change and so the entire amino acid would be different.
C) The amino acid is not changed since the coding sequence was not changed at the 5' position.
D) A premature stop codon caused by this change would result in a truncated polypeptide.
E) Just one amino acid would be changed in the resulting polypeptide.

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