How is the development of autoimmunity normally prevented?
A) T lymphocytes that respond to autoantigens in the thymus undergo clonal deletion.
B) Clonal deletion of T cells and regulatory T cell suppression prevent autoreactive T cell activation.
C) Regulatory T cells suppress autoimmune responses.
D) T lymphocytes require a specific set of cytokine signals to become activated.
E) Clonal deletion of T cells, lack of necessary cytokine signals, and regulatory T cell suppression prevent activation of autoreactive T cells.

Question

Quizplus · Accepted Answer

The development of autoimmunity is normally prevented by a combination of mechanisms: clonal deletion of autoreactive T cells, lack of necessary cytokine signals for activation, and suppression by regulatory T cells.

How Is the Development of Autoimmunity Normally Prevented