In addition to an increase in sensitivity to glutamate, the binding of large amounts of glutamate to its receptors on the postsynaptic membrane also
A) can overwhelm the synapse.
B) stimulates presynaptic autoreceptors and enhances its release.
C) affects other synapses that are close to the first.
D) directly causes more NMDA channels to open.
E) stimulates the release of a paracrine messenger that further increases glutamate release.

Question

Quizplus · Accepted Answer

The binding of large amounts of glutamate can stimulate the release of a paracrine messenger, such as nitric oxide, which can enhance further glutamate release.

In Addition to an Increase in Sensitivity to Glutamate, the Binding