A person taking a histamine (H₂) blocker or a proton pump inhibitor to relieve excess stomach acid production often finds a return of symptoms that is worse with a missed dose. Which statement about the effects these medications have on gastrin is FALSE? A) Acid -blocking medications interrupt the negative feedback on gastrin release and are therefore self -limiting in their use. B) High circulating levels of gastrin accompany acid -blocking medication use and, if interrupted, a pronounced rebound effect of excess stomach acid ensues. C) Acid blockers have no direct effect on gastrin, but inhibit acid production through other mechanisms. D) Decreased acid production inhibits inhibition of gastrin release into the bloodstream, thereby disrupting its negative feedback mechanism. E) Return of symptoms by excess gastrin's influence on acid production stimulates further medication use, thereby leading to a chronic consumption.

Question

Quizplus · Accepted Answer

Acid-blocking medications like histamine blockers and proton pump inhibitors do indeed disrupt the negative feedback mechanism that regulates gastrin release, leading to increased gastrin levels. However, this effect does not make their use self-limiting. Instead, it can lead to a rebound effect of increased acid production when the medication is stopped, contradicting the statement in choice A.

A Person Taking a Histamine (H2) Blocker or a Proton

A Person Taking a Histamine (H₂) Blocker or a Proton