Which Statement Best Describes Why Oxygen Is Unloaded in Tissue

Which statement best describes why oxygen is unloaded in tissue that is highly active?

A) As temperature increases, the carbamino effect causes hemoglobin to release oxygen.
B) As temperature increases, the Bohr effect causes hemoglobin to release oxygen.
C) As temperature increases, the affinity for oxygen to hemoglobin increases, allowing more oxygen to be carried to the tissues.
D) Highly active tissues produce more carbon dioxide, which competes for the heme groups in hemoglobin, thereby displacing oxygen.
E) As temperature increases due to increased metabolism, the affinity of hemoglobin for oxygen is decreased.