A decrease in the affinity of hemoglobin for oxygen caused by the binding of a hydrogen ion to hemoglobin is described by the

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The Bohr effect describes how an increase in the concentration of carbon dioxide or hydrogen ions in the blood leads to a decrease in the affinity of hemoglobin for oxygen. This is because the binding of hydrogen ions (protons) to hemoglobin promotes the release of oxygen, facilitating oxygen delivery to tissues where it is most needed, such as active muscles.

A Decrease in the Affinity of Hemoglobin for Oxygen Caused