Thrombin not only promotes clotting at injury sites, but also indirectly inhibits clotting in healthy tissue.

Question

Quizplus · Accepted Answer

Thrombin has a dual role in the coagulation process: while it promotes clot formation at injury sites by converting fibrinogen to fibrin, it also activates protein C, which in turn inactivates factors Va and VIIIa, thus providing a negative feedback mechanism that prevents clotting in areas where it is not needed.

Thrombin Not Only Promotes Clotting at Injury Sites, but Also