Aspirin Is a Nonsteroidal Anti- Inflammatory Drug (NSAID)that Relieves Pain

Aspirin is a nonsteroidal anti- inflammatory drug (NSAID) that relieves pain. Which mechanism best describes how NSAIDs work?

A) When aspirin dissolves in the interstitial fluid it causes a concentration gradient and fluid is pulled from the cell reducing inflammation.
B) Aspirin decreases the production of thromboxane A2, a chemical involved in blot clot formation, and COX inhibits A2 and, therefore, blood clots do not form and cause pain.
C) The COX receptors have a greater affinity for aspirin and these speed up the reactions of healing.
D) Prostaglandins (PG) are eicosanoids that produce pain and inflammation. Cyclooxygenase (COX) is an essential enzyme in the production of PG and aspirin inhibits COX and therefore relieves pain due to the reduced production of PG.
E) Leukotrienes are eicosanoids that produce pain and inflammation. COX is used in the lipoxygenase pathway and therefore NSAIDs stop the conversion of arachidonic acid to leukotrienes thereby reducing inflammation.